Chronic Centrifugation (Hypergravity) Influences the Circadian System of the Rat  (2001)

Objectives: This study was conducted to quantitate the effect of chronic centrifugation on animal energy expenditure, and to evaluate the response of the DBT and LMA circadian oscillators (biological clocks) to acute hypergravity onset and adaptation to chronic hypergravity exposure. We report herein the analysis of the gross animal locomotor activity (LMA) data (which was measured as an indirect indicator of animal energy expenditure), and the deep body temperature (DBT) data. Our study differs from previous reports on this topic (2,3,6), in that we provide a comprehensive mathematical analysis to quantitate the physiological adaptation of the circadian timing system to three chronic hypergravity “doses” (1.25, 1.5 , and 2 G).

+ Holley, D

+ Holley, D

+ DeRoshia, Charles

+ Moran, M

+ Wade, C

+ Psychophysiological Research Facility

Centrifugation, circadian oscillator, Circadian System, Hypergravity, locomotor activity, Rat

Paper presented at the Future of Chronic Acceleration Meeting in Davis, CA, Jan 31, 2001

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